ABSTRACT
Background: Urolithiasis is a burgeoning disease that results from pathological biomineralization. Daucuscarota L. is a widely consumed food crop with reported nephroprotective and diuretic activity. Its potential for Ashmari bhedan (destruction of stone/calculi) or treatment of urinary calculi has been exploredtraditionally. However, no scientific evidence is available to prove its antiurolithiatic efficacy. Moreover,establishing the antiurolithiatic effects of D. carota, an extensively consumed commodity with numeroushealth benefits, would provide a beneficial dietary measure for the prevention and cure of urolithiasis.Objective: The study aimed at investigating in vivo antiurolithiatic potential of hydroethanolic extract ofD. carota roots against calcium oxalate urolithiasis.Materials and methods: Ethylene glycol and ammonium chloride induced hyperoxaluria model of urolithiasis in male Wistar rats was used for the study. Urine and serum parameters and, kidney histopathology was used to determine the antilithic efficacy of D. carota root extract.Results: D. carota extract significantly ameliorated abnormal urinary levels of calcium, oxalate, phosphate, magnesium, citrate, protein and uric acid in lithogenic rats. Serum BUN, creatinine and uric acidlevels; and calcium, phosphate and oxalate deposition in kidney tissue were also rendered normalfollowing D. carota treatment. D. carota extract also prevented oxidative stress mediated renal tissuedegeneration both prophylactically and curatively.Conclusion: This study suggests antiurolithiatic effect of D. carota roots, which can be attributed to itsanticrystallization property, ability to ameliorate urine and serum biochemistry and renal cellularity